The most significant factor in the successful Spanish conquest of the Aztecs and Incas was C. disease. Although factors such as armor, guns, and horses played roles in the military advantage the Spanish had over indigenous populations, the introduction of diseases like smallpox had a devastating impact on the Aztec and Inca societies, decimating their populations and weakening their ability to resist conquest.
What was the most significant factor in the successful Spanish conquest of the Aztecs and Incas? A. armor B. guns C. disease D. horses
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