The two responses that apply to the significance of the Leo Frank Case are:
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It was an example of African American prejudice in the South.
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It was an example of anti-Semitism in the South.
The Leo Frank case highlighted systemic biases and prejudices, particularly focusing on anti-Semitism, as Frank was a Jewish factory manager wrongfully accused of murdering a young African American girl, Mary Phagan. The case also amplified racial tensions and demonstrated the complexities of societal prejudices in the South during that time.