The question that caused tensions between the federal government and the South Carolina state government during the Nullification Crisis was:
D) Is a state required to abide by a federal law that the state believes is unconstitutional?
During the Nullification Crisis of the early 1830s, South Carolina asserted that it had the right to nullify federal tariffs, citing the belief that the tariffs were unconstitutional and harmful to the state's economy. This led to significant conflict between the state and the federal government.