What is when the brain develops a chemical need for a substance would that be intoxication withdrawal, detoxification or dependence?

Answer 1

That would be dependence. Dependence is when the brain develops a chemical need for a substance in order to function normally. Withdrawal, on the other hand, is the unpleasant physical and psychological symptoms that occur when a person stops using a substance they are dependent on. Detoxification is the process of removing a substance from the body in order to rid the body of its effects.