The substrate for the enzyme DNase is deoxyribonucleic acid (DNA). DNase specifically catalyzes the hydrolysis of the phosphodiester bonds in DNA, breaking it down into smaller oligonucleotides or nucleotides.
The substrate for the enzyme proteinase (or protease) is proteins or peptides. Proteinases catalyze the breakdown of peptide bonds in proteins, resulting in smaller peptides or free amino acids.