To solve the equation \( \frac{8}{5}x = -10 \), follow these steps:
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Multiply both sides by \( \frac{5}{8} \) to isolate \( x \):
\[ x = -10 \times \frac{5}{8} \]
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Calculate the right side:
\[ x = -\frac{50}{8} \]
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Simplify \( -\frac{50}{8} \):
\[ x = -\frac{25}{4} \]
Thus, the solution is:
\[ \boxed{-\frac{25}{4}} \]
So, the correct answer is B: -25/4.