To simplify the expression \(\sqrt{81} \cdot \sqrt{16}\), we can use the property of square roots that states \(\sqrt{a} \cdot \sqrt{b} = \sqrt{a \cdot b}\).
First, let's calculate the square roots:
\[ \sqrt{81} = 9 \]
\[ \sqrt{16} = 4 \]
Now, we multiply these two results together:
\[ \sqrt{81} \cdot \sqrt{16} = 9 \cdot 4 = 36 \]
Thus, the product of the expression in simplest radical form is:
\[ \boxed{36} \]