The quote suggests that individuals who possess wealth (represented by "gold") but lack the wisdom or purpose on how to use it may indulge in extravagant and reckless behavior (referred to as "profligacy"). This indulgence ultimately leads to their downfall or destruction, akin to "flies stuck in honey," which implies being trapped or overwhelmed by something that initially seems attractive but becomes detrimental.
In essence, the best interpretation of this quote highlights the dangers of excess and the importance of using resources wisely; without direction or moderation, even valuable assets can lead to one's ruin. It serves as a cautionary reminder that wealth alone does not guarantee success or happiness; rather, it must be managed thoughtfully to avoid negative consequences.