The best evidence that supports the theory of a large asteroid striking the Earth and causing mass extinction, particularly the event that is believed to have led to the extinction of the dinosaurs around 66 million years ago, is:
C. Iridium found only in asteroid is found worldwide in the same rock layer.
This iridium layer, often referred to as the "Cretaceous-Paleogene (K-Pg) boundary" iridium layer, is a key piece of evidence. Iridium is rare on Earth's surface but more common in asteroids. The global distribution of this layer suggests a massive impact event, consistent with the hypothesis of an asteroid strike.
While fossil evidence (B) can provide insights into extinction events, and carbon dating (A) can help date the layers, the specific iridium anomaly serves as direct evidence supporting the asteroid impact theory.