The victory in the War of 1812 and the subsequent Treaty of Ghent had significant effects on Native Americans, primarily in terms of land and U.S. expansion. Here are the relevant points:
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It opened lands in the Great Lakes region to U.S. settlement: The defeat of Native American coalitions that allied with the British during the War of 1812 diminished their ability to resist American encroachment on their lands, leading to increased U.S. settlement in the region.
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It compelled most Native Americans to migrate north to British Canada: As U.S. forces expanded into territories traditionally held by Native Americans and following their defeat, many tribes felt pressured to relocate their communities northward to seek refuge and maintain their autonomy under British protection.
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It led Native Americans to form a confederation to resist U.S. expansion: In the wake of the war, some Native American leaders, most notably Tecumseh, sought to create a confederation of tribes to resist U.S. expansion, although this effort was ultimately unsuccessful after Tecumseh's death in battle.
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It secured their land claims east of the Mississippi River: This statement is less applicable overall. While certain tribes had treaties that recognized their land holdings, the outcomes of the War of 1812 largely undermined Native American land claims as the U.S. government continued its policy of westward expansion.
Overall, the significance of the War of 1812 and the Treaty of Ghent for Native Americans was largely negative, leading to a loss of territorial claims and increased pressure to relocate or resist U.S. forces.
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