The War of 1812 and the Treaty of Ghent had significant effects on Native Americans, particularly as it related to their land and sovereignty:
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It opened lands in the Great Lakes region to U.S. settlement. - This statement is accurate, as the U.S. victory and the subsequent treaty diminished Native American resistance in the region, leading to increased settlement by American migrants.
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It secured their land claims east of the Mississippi River. - This statement is not accurate. The outcome of the war did not secure Native American land claims; instead, U.S. expansion continued, often at the expense of Indigenous territories.
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It led Native Americans to form a confederation to resist U.S. expansion. - This statement is also accurate, particularly in reference to leaders such as Tecumseh, who sought to unite various tribes to resist growing American encroachments on their lands.
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It compelled most Native Americans to migrate north to British Canada. - This statement has some basis, but it was not the primary outcome of the Treaty of Ghent or the war. While some Native Americans did seek refuge in Canada, the overall impact was more about the erosion of their territories and influence.
Overall, the most accurate assessment of the immediate effects of the War of 1812 and the Treaty of Ghent would be that it opened lands in the Great Lakes region to U.S. settlement and led to efforts among Native Americans to form confederations for resistance.