what are the tenets of pharmacology

Question

I found more then three "basic tenets of pharmacology" online:

The dose should be no larger than that necessary for the desired effect

The drug molecules must get so close to the cellular molecules that the function of the latter is altered

The drug molecules must be ‘bound’ to particular constituents of cells and tissues in order to produce an effect

Association of a drug molecule with its binding site leads to a physiological response

Most drug binds to protein molecules