The best summary of how Columbus's and Vasco da Gama's motivations were different is:
B. Both had three motivating factors; however, Columbus achieved spices, God, and glory, whereas da Gama achieved glory and silk.
Columbus was primarily focused on seeking new routes to Asia for trade, spreading Christianity, and gaining personal glory. Vasco da Gama, on the other hand, sought to establish a direct maritime route to India for precious spices and luxury goods, as well as to spread Christianity, but his achievements were more centered on silk and trade.