To simplify the expression \(2^4 \times 2^2\) using the Product Rule of Exponents, you can follow the rule which states that when multiplying two powers with the same base, you add the exponents:
\[ a^m \times a^n = a^{m+n} \]
Here, the base \(a\) is \(2\), \(m = 4\), and \(n = 2\).
So, we can add the exponents:
\[ 2^4 \times 2^2 = 2^{4 + 2} = 2^6 \]
Thus, the simplified expression is:
\[ 2^6 \]
If you want the numerical value, \(2^6 = 64\).