To simplify the expression \((78^8)^6\) using the power rule of exponents, we apply the rule which states that \((a^m)^n = a^{m \cdot n}\).
In this case, we have:
\[ (78^8)^6 = 78^{8 \cdot 6} \]
Now calculate \(8 \cdot 6\):
\[ 8 \cdot 6 = 48 \]
Therefore, the simplified expression is:
\[ (78^8)^6 = 78^{48} \]
So the final answer is:
\[ 78^{48} \]