To determine which two elements most likely have similar properties, we can look at their positions in the periodic table. Elements in the same group (column) generally exhibit similar chemical properties.
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Cs and Rn: Cesium (Cs) is an alkali metal (Group 1), while Radon (Rn) is a noble gas (Group 18). They do not share similar properties.
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Ca and Sc: Calcium (Ca) is an alkaline earth metal (Group 2), and Scandium (Sc) is a transition metal (Group 3). They are not in the same group and do not share strong similarities.
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Li and Fr: Lithium (Li) is also an alkali metal (Group 1), and Francium (Fr) is another alkali metal found in the same group. They have similar properties.
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F and Ne: Fluorine (F) is a halogen (Group 17), and Neon (Ne) is a noble gas (Group 18). They do not share similar properties.
Based on this analysis, the two elements that most likely have similar properties are Li and Fr (Lithium and Francium).