To calculate the slope of the line passing through the points \((-4, 5)\) and \((8, -4)\), we use the formula for the slope \(m\):
\[ m = \frac{y_2 - y_1}{x_2 - x_1} \]
Here, \((x_1, y_1) = (-4, 5)\) and \((x_2, y_2) = (8, -4)\).
Now substituting the values into the formula:
\[ m = \frac{-4 - 5}{8 - (-4)} = \frac{-4 - 5}{8 + 4} = \frac{-9}{12} \]
To simplify \(\frac{-9}{12}\), we can divide both the numerator and the denominator by their greatest common divisor, which is 3:
\[ \frac{-9 \div 3}{12 \div 3} = \frac{-3}{4} \]
Thus, the slope of the line is:
\[ \boxed{-\frac{3}{4}} \]