In this scenario, Lexi folds her paper such that point C is on top of point D, which implies that points C and D are reflected over the line QR. The point E where the fold intersects the line segment (CD) is the midpoint of segment CD. Therefore, given the context, the line that acts as the segment bisector of CD would be the line that passes through point E and is perpendicular to CD.
Thus, the segment bisector is QR←→.
So, the correct response is:
QR←→