Based on the chart, the correct response to how westward expansion affected slavery in the United States between 1820 and 1850 is:
The slave population roughly doubled as several new slave states were admitted to the Union.
This is supported by the data showing an increase in the enslaved population from 1,539,038 in 1820 to 3,204,313 in 1850. This significant growth indicates that the expansion of slave states contributed to the increase in the number of enslaved people.