To effectively subtract \(8.03 \times 10^{-8}\) from \(2.56 \times 10^{-2}\), we first align the powers of 10. Since \(2.56 \times 10^{-2}\) has a power of \(-2\) and \(8.03 \times 10^{-8}\) has a power of \(-8\), we can convert \(8.03 \times 10^{-8}\) to the same power as \(2.56 \times 10^{-2}\).
We can rewrite \(8.03 \times 10^{-8}\) in terms of \(10^{-2}\) by multiplying it by \(10^{-6}\):
\[ 8.03 \times 10^{-8} = 8.03 \times 10^{-8 + 6} \times 10^{-6} = 8.03 \times 10^{-2} \times 10^{-6} = 0.0000803. \]
Now we can express \(2.56 \times 10^{-2}\) as a decimal as well:
\[ 2.56 \times 10^{-2} = 0.0256. \]
Now we can perform the subtraction:
\[ 0.0256 - 0.0000000803. \]
Since \(0.0000000803\) is extremely small in comparison to \(0.0256\), we can say:
\[ 0.0256 - 0.0000000803 \approx 0.0256. \]
To get a precise result in scientific notation, we can express it as:
\[ \approx 2.56 \times 10^{-2}. \]
Therefore, the final answer, accounting for the negligible effect of \(8.03 \times 10^{-8}\), is:
\[ \boxed{2.56 \times 10^{-2}}. \]