Without seeing the specific political cartoon you're referring to, it's difficult to provide a definitive answer. However, I can give you some context about each option:
A. The Civil War - Political cartoons from this era often depicted issues related to slavery, states' rights, and the conflict between the North and South.
B. The Mexican War - Cartoons from this period might focus on territorial expansion and the idea of Manifest Destiny.
C. The Monroe Doctrine - This principle, established in 1823, warned European powers against colonization in the Americas, and cartoons might critique foreign influence or intervention.
D. The American Revolution - Cartoons from this time could highlight colonial resistance to British rule and issues of taxation and representation.
If you can describe the cartoon or its key themes, I could help identify the most relevant option.