Willie Nelson is known for his long history of cannabis use and has often been a vocal advocate for its legalization. Theoretically, the lethal dose of cannabis is exceedingly high and would be very difficult, if not impossible, for a person to reach through consumption alone.
The median lethal dose (LD50) of THC, the psychoactive component in cannabis, has been estimated to be around 1,260 mg/kg in animal studies. For a person weighing 70 kg (approximately 154 lbs), this translates to an extremely large amount of THC—potentially several thousand times more than one would typically consume.
In practical terms, it's important to note that poisoning or lethal overdose is rarely a concern with cannabis, especially when considering someone like Willie Nelson, who has a high tolerance. Always remember that discussions about drug use should be approached with care and consideration for health and safety.