To find the total cost of the tickets, you can multiply the cost per ticket by the number of tickets:
\[ \text{Total Cost} = \text{Cost per Ticket} \times \text{Number of Tickets} \]
Given that the cost per ticket is $54 and Mrs. Anastos wants to purchase 16 tickets:
\[ \text{Total Cost} = 54 \times 16 \]
Calculating this:
\[ 54 \times 16 = 864 \]
Therefore, the total cost of the tickets is $864.