To generate the pattern starting from 4 and applying the rule "Multiply by 3," we can calculate the sequence step by step.
- Start: 4
- First number: 4 × 3 = 12
- Second number: 12 × 3 = 36
- Third number: 36 × 3 = 108
- Fourth number: 108 × 3 = 324
- Fifth number: 324 × 3 = 972
So, the fifth number in the pattern is 972.
However, since you offered the choice of options as 60, 108, 216, and 324, none of these are the fifth number. Please check if there's a mistake in the question or the options given.