Based on the information in the graph regarding the fluctuating use of herbicide-tolerant (HT) genetically modified crops in the United States, the most likely change that occurred on U.S. farms during that period is:
C. Reduced presence of weeds in cotton fields.
This is because the introduction and increased use of herbicide-tolerant crops are associated with decreased weed populations due to targeted herbicide application, leading to a more effective control of weeds. The other options do not directly correlate with the information normally illustrated in such a graph.