The correct response regarding the end behavior of the volume of a sphere as the radius changes is:
As the radius increases to infinity, the volume of the sphere will increase to infinity.
This is because the volume \( V \) of a sphere is directly proportional to the cube of the radius \( r \), as indicated by the equation \( V = \frac{43}{3} \pi r^3 \). As \( r \) becomes larger and approaches infinity, \( r^3 \) also approaches infinity, leading to the conclusion that the volume \( V \) will also increase without bound.
The other options involving negative infinity are not applicable in the context of physical dimensions, as the radius of a sphere cannot be negative.