Tay-Sachs disease is a hereditary disease that kills 1 in 360,000 individuals in the general population. Individuals homozygous for the defective allele have Tay-Sachs disease and die at an early age.Studies show that heterozygous individuals have a higher rate of survival against tuberculosis than the rest of the population.Biochemical tests can determine if parents are carriers.

a. What type of inheritance is demonstrated by Tay-Sachs disease?
My work:The type of inheritance that is demonstrated by Tay-Sachs disease is Autosomal Dominant Inheritance.

b. A young couple decide to have genetic screening done to determine if they were carriers of Tay-Sachs. If both individuals were carriers what percentage of their offspring would be predicted to have protection from tuberculosis, but not have Tay-Sachs disease.(Show all your work)

My work: 35%

1 answer

a. How can it be dominant, if there are carriers who do not have the disease?

b. No, use Punnett Square:

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