To find out how many pictures the scrapbook holds in total, we need to multiply the number of pages by the number of pictures each page can hold.
The scrapbook has 125 pages, and each page holds 16 pictures.
So, we calculate:
\[ 125 \text{ pages} \times 16 \text{ pictures per page} = 2000 \text{ pictures} \]
Therefore, the scrapbook holds 2,000 pictures in all.