summarize this Several experimental studies have shown that smoking induces pathological and functional changes in the exocrine pancreas. Nicotine induces damage through signal transduction pathways in pancreatic acinar cells, leading to elevated levels of intracellular calcium release and/or impaired pancreatic blood flow.

Answer 1

Experimental studies have demonstrated that smoking causes harmful effects on the exocrine pancreas, including damage to pancreatic acinar cells through signal transduction pathways, resulting in increased intracellular calcium release and compromised pancreatic blood flow.