To solve the quadratic equation \(x^2 - 16x + 64 = 0\) using the perfect square trinomial pattern, we can first recognize that the left side can be factored.
The expression can be rewritten as:
\[ (x - 8)^2 = 0 \]
To solve for \(x\), we take the square root of both sides:
\[ x - 8 = 0 \]
Adding 8 to both sides gives:
\[ x = 8 \]
Thus, the solution to the equation \(x^2 - 16x + 64 = 0\) is:
\[ \boxed{8} \]