To simplify the expression
\[ \frac{243 y^5 z^8}{-27 y^9 z^{-15}}, \]
we will proceed with the simplification step by step.
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Simplify the numerical coefficients:
The coefficient in the numerator is \(243\) and in the denominator is \(-27\).
\[ \frac{243}{-27} = -9. \]
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Simplify the \(y\) terms:
We have \(y^5\) in the numerator and \(y^9\) in the denominator.
Using the property of exponents \(\frac{a^m}{a^n} = a^{m-n}\), we get:
\[ \frac{y^5}{y^9} = y^{5-9} = y^{-4}. \]
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Simplify the \(z\) terms:
We have \(z^8\) in the numerator and \(z^{-15}\) in the denominator.
Applying the same property, we have:
\[ \frac{z^8}{z^{-15}} = z^{8 - (-15)} = z^{8 + 15} = z^{23}. \]
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Combine all parts:
Now we can combine the results of our simplifications:
\[ -9 y^{-4} z^{23}. \]
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Rewrite \(y^{-4}\) (if needed):
If we want to express \(y^{-4}\) in a different way, we can write it as:
\[ \frac{-9 z^{23}}{y^4}. \]
Thus, the simplified expression, in either form, is:
\[ -9 y^{-4} z^{23} \quad \text{or} \quad \frac{-9 z^{23}}{y^4}. \]