To simplify the expression \( \frac{2}{8}x + \frac{3}{10}y - \frac{5}{8}x + \frac{4}{10}y \), we will combine like terms.
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Combine the \( x \) terms: \[ \frac{2}{8}x - \frac{5}{8}x = \left(\frac{2}{8} - \frac{5}{8}\right)x = -\frac{3}{8}x \]
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Combine the \( y \) terms: \[ \frac{3}{10}y + \frac{4}{10}y = \left(\frac{3}{10} + \frac{4}{10}\right)y = \frac{7}{10}y \]
Now we can write the combined expression: \[ -\frac{3}{8}x + \frac{7}{10}y \]
Thus, the simplified expression is: \[ -\frac{3}{8}x + \frac{7}{10}y \]
So, the correct response is: \[ \text{-}\frac{3}{8}x + \frac{7}{10}y \]