To simplify \((5x^4y^{10})^2\):
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Apply the power of a product rule, which states that \((ab)^n = a^n \cdot b^n\).
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For the expression \((5)^2\), \( (x^4)^2\), and \( (y^{10})^2\):
- \((5)^2 = 25\)
- \((x^4)^2 = x^{4 \times 2} = x^8\)
- \((y^{10})^2 = y^{10 \times 2} = y^{20}\)
Combining these results gives:
\[ (5x^4y^{10})^2 = 25x^8y^{20} \]
Looking at the multiple choice answers, the correct simplification is:
25, x, to the power 8, y, to the power 20.