The following statements are accurate regarding the events in the Spanish Conquest of the Aztec Empire:
- Malinche helped the Spanish ally with Aztec enemies.
- A battle broke out between the Aztecs and the Spanish in which Moctezuma was killed.
- Caribbean colonies were used as a base to conquer the mainland.
The statement that "The Aztecs successfully defended Tenochtitlán from Spanish invaders" is not accurate, as the city eventually fell to the Spanish forces in 1521.