Based on the context of the mouse coloration case study, a plausible hypothesis that researchers might explore regarding the role of predators in natural selection could be:
"If a population of beach mice is exposed to a different predator that has a contrasting hunting strategy or visual capabilities compared to the native predator (owls), then the coloration of the beach mice will adapt to enhance their survival against that specific predator."
This hypothesis allows researchers to study how different predator types influence the selection pressures on the coloration of the beach mice, thereby providing insights into the dynamic interactions between prey and predator in the process of natural selection.