To express the number 2.81E4 in scientific notation, we note that E4 means "times ten raised to the power of 4". Therefore, 2.81E4 can be rewritten as:
\[ 2.81 \times 10^4 \]
This is already in proper scientific notation, as it follows the format of \( a \times 10^n \), where \( 1 \leq a < 10 \) and \( n \) is an integer.
Thus, the number 2.81E4 in scientific notation is:
\[ 2.81 \times 10^4 \]