From 300 CE to 600 CE, the practice of Christianity underwent significant changes as it expanded geographically and culturally.
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Geographical Spread: The most notable change was the significant increase in the areas where Christianity was practiced. In 300 CE, Christianity was limited to small areas along the coasts of Spain, France, Italy, Greece, Turkey, and North Africa. By 600 CE, the religion had spread to encompass all of Spain, France, Ireland, western Britain, and established a stronger presence in the previously mentioned regions. This demonstrates a substantial geographical expansion throughout Europe.
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Cultural Integration: As Christianity spread to various regions in Europe, it also began integrating with local cultures and practices, influencing social structures and communities.
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Emerging Communities: The spread included not only urban centers but also rural areas, with Christian communities becoming more established in previously less-represented regions.
The best summary of this change from the options provided would be "It spread throughout Europe," as it captures the broad geographical expansion and the significant increase in the number of adherents compared to the earlier period.