resulted in the deaths of approximately a third of the Native American Population during de Soto’s exploration

Warfare
Enslavement
Relaxation
Disease

1 answer

The significant decline in the Native American population during Hernán de Soto's exploration is primarily attributed to disease. When European explorers and colonists arrived in the Americas, they brought with them diseases to which Indigenous populations had no immunity, leading to widespread epidemics and high mortality rates. While warfare and enslavement also contributed to the decline, disease was the main factor resulting in the deaths of approximately a third of the Native American population during that time.