The correct answer is:
D. by developing new chemicals with new properties
Engineers solved the problem of creating effective refrigerants for small-scale refrigerators and air conditioners by developing synthetic chemicals that had desirable properties for refrigeration, such as low toxicity, low flammability, and efficient heat absorption and release. These new refrigerants, such as chlorofluorocarbons (CFCs) and hydrofluorocarbons (HFCs), offered better performance and safety compared to earlier natural refrigerants.