To simplify the expression \(2^4 \cdot 2^2\) using the Product Rule of Exponents, you add the exponents since the bases are the same.
The Product Rule states that \(a^m \cdot a^n = a^{m+n}\).
Applying this rule here:
\[ 2^4 \cdot 2^2 = 2^{4+2} = 2^6 \]
So, the simplified expression is \(2^6\).