The best inference about the Gold Rush’s impact on the city of San Francisco, based on the information in the chart, is:
The mass migration of forty-niners transformed San Francisco into an economic hub practically overnight.
This is supported by the dramatic increase in population from just 850 in April 1848 to 25,000 by December 1849, indicating that the Gold Rush attracted a significant number of people and quickly changed the city's demographics and economic landscape.