To find out how many cans are in twelve sixpacks of soda, you can multiply the number of cans in one sixpack by the number of sixpacks.
Since one sixpack contains 6 cans, you would calculate:
\[ 6 \text{ cans/sixpack} \times 12 \text{ sixpacks} = 72 \text{ cans} \]
Therefore, in twelve sixpacks of soda, there are 72 cans.