The second attempt by the French to colonize South Carolina, led by Huguenots, is generally considered more successful. This success can be attributed to the Huguenots' ability to establish a settlement that lasted longer than the first attempt, largely due to their collaboration with the English settlers in the region, which provided them with much-needed support and resources.
In contrast, the first attempt, although it resulted in the establishment of Charlesfort, ultimately failed to sustain itself. The settlers faced numerous challenges, including conflicts with the indigenous population and a lack of supplies, which led to its abandonment.
Thus, while the first attempt laid the groundwork for future colonization efforts, the second attempt was able to establish a more enduring presence due to the support and collaboration with other settlers in the area.