Need help with the following questions:

Question

Q1) Mrs Chen ________ for the doctor's clinic already.
1) left 2) has left
3) had left 4) was leaving
Is the answer (1) or (2)?

Q2) John ______ to the library since nine o'clock this morning, he should be back soon.
1) goes 2) went
3) is going 4) has gone
Is the answer (2) or (4)?

Q3) She was very upset ______ the way those boys treated the poor kitten.
1) about 2) at
3) on 4) after
Is the answer (1) or (2)? Or are both answers acceptable?
How about "with" as in "upset with"?

Answer 1

Q1) 2

Q2) 2

Q3) Yes, both 1 and 2 are correct.

You could use "with" in this sentence:
She was very upset with those boys.

Answer 2

None of the answers is correct for 2).

Answer 3

Q2) John has been at the library since nine o'clock this morning; he should be back soon.

or

Q2) John went to the library at nine o'clock this morning; he should be back soon.