The statement that does not directly apply to meiosis, sexual reproduction, and genetic variation is:
A Meiosis is preceded by DNA replication of chromosomes in the nucleus of the mother cell.
While it is true that DNA replication occurs before meiosis, this process itself does not contribute to genetic variation. The other options (B, C, and D) specifically describe mechanisms that create genetic variation (crossing over, random chromosome contribution during fertilization, and independent assortment). Therefore, option A is the correct choice as the exception.