The statement that best analyzes how Hugo uses irony in this example is: Hugo uses dramatic irony by creating a situation where the audience knows something that the main character does not.
In this case, the audience understands that the gypsies are actually coming to rescue Esmeralda, while Quasimodo mistakenly believes they are a threat. This gap in knowledge creates tension and highlights the tragic nature of Quasimodo's actions, illustrating the theme of misunderstanding and the complexities of loyalty and protection.