The correct response based on the excerpt from "Brutus No. 1" would be B oppose the ratification of the Constitution.
The author expresses concerns about the diverse interests and customs of different states in a republic, suggesting that a legislature formed from such diverse representatives would be prone to conflict and inefficiency. This sentiment aligns with Anti-Federalist views, which typically opposed the ratification of the Constitution due to fears that a strong central government would not adequately represent the varied interests of the states.