In 5 - 7 sentences, explain how in Connection #1 with the concepts Indian Removal Act, Manifest Destiny, American System, Missouri Compromise, and 2nd Great Awakening all relate to each other.

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The Indian Removal Act, Manifest Destiny, the American System, the Missouri Compromise, and the Second Great Awakening are interconnected concepts that reflect the dynamics of 19th-century America. The Indian Removal Act epitomized the belief in Manifest Destiny—the idea that the U.S. was destined to expand across the continent—by justifying the forced displacement of Native Americans from their ancestral lands. This expansionist vision often clashed with issues of slavery, leading to the Missouri Compromise, which was an attempt to balance free and slave states as new territories were explored and settled. In the economic realm, the American System aimed to unify the nation through internal improvements and tariff support, which facilitated westward expansion and settlement. Meanwhile, the Second Great Awakening provided a religious justification for expansion, as many Americans believed they were chosen to spread democracy and Christianity across the continent. Together, these concepts illustrate the complex interplay of expansion, economics, and social change during a transformative period in American history.