Question

In 2-3 sentences summarize why Hemophilia, a hereditary bleeding disorder, typically affects males more than females.

Answer 1

Hemophilia is a hereditary bleeding disorder caused by mutations in genes responsible for blood clotting factors, particularly the factor VIII (Hemophilia A) or factor IX (Hemophilia B). These genes are located on the X chromosome, and since males have only one X chromosome, a single mutated copy results in the disease, while females have two X chromosomes, allowing a normal copy to compensate for the defective one, typically preventing the manifestation of the disorder.