In the case of an X-linked dominant disorder, the frequency of the disorder would generally vary between males and females in the following way:
Males would display this disorder with lesser frequency than females.
Here's the reasoning behind it:
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Males have one X chromosome (XY): If a male inherits the X-linked dominant allele, he will express the disorder. There is no backup X chromosome to mask the effect of that allele.
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Females have two X chromosomes (XX): A female can inherit the X-linked dominant allele from one parent and still have a second X chromosome. If she inherits the disorder allele from one parent, she will express the disorder; however, if she inherits it from both parents, it can lead to a more severe manifestation if the disorder has variable expressivity or if additional mutations are present.
Because females have two X chromosomes, they have a higher chance of displaying the disorder compared to males. However, each affected male will display the disorder, while females can be heterozygous, which may sometimes lead to milder manifestations.
In summary, females would display this disorder with greater frequency than males.
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